Early diagnosis
Saves happy lives.

Key Facts

Ovarian Cancer ranks fifth in leading cancer deaths among women, accounting for more deaths than any other female reproductive system cancer. In 2023, it is estimated that approximately 19,710 new ovarian cancer cases will be diagnosed1. Annually, nearly 20,000 new ovarian cases are identified in the U.S. and for every 10 women diagnosed, 6 die for this disease. Some Key Facts:

  • The five-year survival rate is 92% for women with stage I Epithelial Ovarian Cancers (EOC).

  • Less than 20% of ovarian cancers are found in the early stages before they spread beyond the ovary (i.e. most cases are identified at Stages 3-4).

  • However, survival rates decline dramatically to 17% to 28% for those with advanced-stage tumors.

Background

There are several different subtypes of Epithelial Ovarian Cancer (EOC) including:

  • Serous
  • Endometroid
  • Mucinous
  • Clear Cell

HE4 complements CA 125 as an ovarian cancer marker. The combination of CA 125 and HE4 has higher sensitivity than either marker alone particularly in premenopausal women. HE4, together with CA 125 and menopausal status, make up the Risk of Malignancy Algorithm (ROMA) use to assess risk of ovarian cancer in patients with a pelvic mass, who are scheduled for surgery.

The ROMA score is used by Obstetricians and Gynecologists to appropriately triage patients, leading to improved patient care and decreased mortality.

Clinical Case Studies

Presented at the ACOG District XII 2022 Annual Meeting in Orlando

Clinical Case #1:

32-year-old premenopausal with pelvic pain

Dr. Richard Moore discusses this clinical case study at the ACOG District XII 2022 Annual District Meeting in Orlando.

Clinical Case #2:

46-year-old premenopausal with an adnexal mass

Dr. Richard Moore discusses this clinical case study at the ACOG District XII 2022 Annual District Meeting in Orlando.

Clinical Case #3:

72-year-old with BRCA-1 gene

Dr. Richard Moore discusses this clinical case study at the ACOG District XII 2022 Annual District Meeting in Orlando.

Learn more about HE4 and ROMA

Learn more about HE4 Learn more about ROMA