Healthcare Professionals

How to Read the Test

A Risk of Ovarian Malignancy Algorithm (ROMA) classifies patients as being at low or high risk for malignant disease20

  • ROMA calculates a risk of finding ovarian cancer during surgery
  • ROMA classifies patients as being at low or high risk for malignant disease

The clinical study conclusions are as follows19

  • In our study at a set specificity of 75% the sensitivity for epithelial ovarian cancer and low malignant potential tumors of the assay was 89% for all patients with a 94% Negative Predictive Value (NPV) for pre and post menopausal women.
  • The following cutpoints were used to reach our set level of specificity when using the HE4 assay and the ARCHITECT CA125II assay.
    • Premenopausal:
      • ROMA Value ≥ 13.1% High risk of finding epithelial ovarian cancer
      • ROMA Value < 13.1% Low risk of finding epithelial ovarian cancer
    • Postmenopausal:
      • ROMA Value ≥ 27.7% High risk of finding epithelial ovarian cancer
      • ROMA Value < 27.7% Low risk of finding epithelial ovarian cancer